Characterization of Clearance Mechanisms in an All-Human Cell Based Tri-Culture System
Results show the triculture system represents a convenient, stable, all-human hepatic culture system that maintains both hepatocellular morphology and various metabolic functions for up to 1 month.
Assessing the In Vitro In Vivo Correlation of Small Molecule Metabolism in Three Long-term Primary Human Hepatocyte Culture Models
The objective of this study, performed by Boehringer Ingelheim, was to compare the performance of hepatocytes in suspension, HepatoPac, spheroids, and LifeNet Health's Triculture system as in vitro tools to generate Phase I and II metabolites observed in vivo.
Cryopreserved Primary Human Thyrocytes for Screening of Thyroid Disruptive Chemicals
Cryopreserved primary human thyrocytes produced robust and reproducible levels of key thyroid markers and could represent a valuable tool to prioritize TDCs and reveal key differences in MOAs between species.
