Ocular Services
The cornea of the eye is particularly sensitive to injury due to a lack of protective barriers. LifeNet Health offers several assays designed to predict both GHS hazard classification as well as irritation potency, which provides a quantitative assessment of potential irritation to the ocular epithelium. In addition, we can provide quantitative data on ocular pain based on the activation of transient receptor potential vanilloid 1 (TRPV1) nociceptor.
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Tests We Offer
- Ocular Irritation – Hazard Assessment (OECD 492)
- Ocular Irritation - Potency Assessment (ET50 Method)
- Eye Damage - Short-Time Exposure Assay (OECD 491)
- Ocular Pain (Nociceptor Neurons): TRPV1 Assay
Expert Regulatory Guidance
- FDA
- EPA
- Health Canada
- European Food Safety Association
- European Medicines Agency
Our Process Sets Us Apart From Other Laboratories
Consultation – We partner with you to determine the best approach, offering customized study plans that draw from our 60-plus years of combined in vitro testing experience. We may recommend utilizing more than one assay when performing a thorough cytotoxicity screening.
Assay Development – We develop and validate your assay using many different cell models, with an emphasis on all-human primary cells and biospecimens to simulate in vitro conditions, which provides more relevant, reliable results than traditional testing methods. This is part of our commitment to advancing alternative methods to support organizations in moving away from traditional animal-based models.
Data Analysis – We provide expert data analysis, including offering adaptable options when needed based on early results.
Results Review – Our clear, concise reports bring simplicity to your biggest data challenges, putting your organization in the best position for regulatory reviews. We may suggest follow-up studies to further your organization’s research goals.
Our facilities are compliant with Good Laboratory Practices and Good In Vitro Method Practices (OECD 286).