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Hepatocytes
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Brightfield image of adult primary human hepatocytes at day 4 of culture
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LifeNet Health LifeSciences offers a large inventory of primary human hepatocytes in plateable and suspension categories. Inventory includes cells from both healthy and diseased tissue.


Hepatocytes make up approximately 60% of the liver and perform multiple functions including protein synthesis and storage, carbohydrate metabolism, lipid metabolism, and detoxification. Primary human hepatocytes are the gold standard for metabolism, drug-drug interaction, and toxicity studies.

  • Comprehensive donor medical and social history provided
  • Donor-matched cells and tissue samples
  • Over 80 lots in inventory
  • Average lot size >450 vials
  • Histopathology report includes Non-Alcoholic Fatty Liver Disease (NAFLD) activity score (NAS) along with H&E and Trichrome stained images
  • Access to technical expertise and guidance from LifeSciences’ team of scientists
  • Optimized Hepatocyte Thawing, Plating, and Culture Media
  • Viability ≥70%
  • Yield ≥5.0 X 106 cells/vial
  • Phase I and II Enzyme Activity
  • Histopathology assessment of tissue of origin by board-certified pathologist; NAS* and fibrosis stage** provided
  • Induction of CYP3A4, CYP2B6, and CYP1A2 mRNA and specific activity for adult mid- and long-term plateable categories
  • Vials of cryopreserved cells shipped and stored at ≤-135°C
*NAFLD (Non-Alcoholic Fatty Liver Disease) score (NAS) was assigned according to the standards of the NASH CRN Scoring System (Hepatology 41: 1313-1321, 2005).
**Inflammation and fibrosis were assessed using standard Batts-Ludwig scoring methodology (Scale, 0-4, American Journal of Surgical Pathology 19: 1409-1417, 1995).

Human Hepatocytes are suitable for a range of applications, including

  • Metabolic clearance
  • Drug-Drug interaction
  • Disease modeling
  • Transporter assays
  • Pharmacogenomics studies
  • 2D and 3D cell culture
Hepatocyte Graph Img

Comprehensive Portfolio of Liver Cells

200+

Lots

0-6

Nas Scores

0-4

Fibrosis Stages