Webinars
Our free webinars offer the latest ideas and insights from life sciences experts at LifeNet Health and beyond. Explore the options below. Topics include primary human hepatocytes, biospecimens, hepatic in vitro systems, cytotoxicity testing, 3D thyroid microtissue, liver non-parenchymal cells, and more.
- Advancing Drug-Drug Interaction Predictions: Utilizing TruVivo®, an All-Human 2D+ Hepatic SystemJun
Jun 17, 2025 @ 11:00 am EST
Accurate prediction of drug-drug interactions (DDIs) remains a cornerstone in the development of safe and effective therapeutics. Traditional in vitro models, particularly hepatocyte monocultures, often fall short in reliably forecasting the induction of drug-metabolizing enzymes and transporters beyond CYP3A, such as CYP2C isoforms, UDP-glucuronosyltransferases (UGTs), and P-glycoprotein (P-gp). This limitation poses challenges in assessing the clinical risk associated with new chemical entities, especially when complex interactions like simultaneous induction and inhibition occur.
This webinar introduces the TruVivo®, an all-human 2D+ Hepatic System – a novel in vitro system comprising hepatocytes, stromal, and epithelial feeder cells. We will explore how TruVivo® addresses the shortcomings of traditional models by providing consistent and well-defined induction responses across multiple enzymes and transporters.
Key discussion points will include:
- Validation of TruVivo® for predicting induction of CYP2C8, CYP2C9, CYP2C19, UGT1A4, CYP3A4, and P-gp.
- Application of TruVivo® in delineating complex DDIs involving co-inducers and inhibitors.
- Case studies demonstrating the platform's utility in in situ DDI experiments using clinically relevant drug concentrations.
Attendees will gain insights into how TruVivo® enhances the predictive accuracy of DDI assessments, potentially reducing the need for extensive clinical interaction studies and accelerating the drug development process.
Guest Speaker: Diane Ramsden, PhD, Senior Director DMPK and Toxicology at Korro Bio
Bio:
Diane Ramsden, PhD, is Senior Director and Head of DMPK at Korro Bio, where she leads preclinical development for RNA editing therapeutics. She brings over 20 years of pharmaceutical industry experience, with prior leadership roles at AstraZeneca and Takeda, supporting drug development across diverse modalities including small molecules, PROTACs, mAbs, ADCs, RNAi, and microbiome-based therapies. Her work spans therapeutic areas such as oncology, GI, neuroscience, cardiometabolic, respiratory, and rare diseases.
She has authored over 50 scientific publications and delivered more than 20 invited talks. She actively contributes to industry consortia advancing in vitro DDI prediction, serves on the editorial board of Drug Metabolism and Disposition, and is part of the PBSS Boston scientific committee. Her research focuses on mechanistic understanding of therapeutic disposition using in vitro and in vivo models.
Recorded Webinars
Browse our collection of previously recorded webinars
- Improved Clearance Predictions for Aldehyde Oxidase Substrates Using TruVivo, a Novel Human Hepatocyte Model
- Toxicity Transformed: Leveraging AI and TruVivo® to Redefine Risk Assessment
- Innovative Approaches to Assessing Thyroid Disruption
- Exploring TruVivo, Enhancing Liver Disease Studies with an All-Human 2D+ Hepatic System
- TruVivo is a Promising New Tool for Toxicity Testing
- Human Biospecimens Unveiled: Navigating Cutting-Edge Standards for Research
- Cell Selection for In Vitro Applications: Maximizing Translational Success
- Evaluation of TruVivo, an All-Human Hepatocyte Model, for Mechanistic DMPK Investigations
- Unveiling New Insights: The Latest Application Data from TruVivo
- Developing an In Vitro Integrated Organ Model for Pharmacokinetic and ADME Predictions
- Human Hepatocyte Tri-Culture System: A Convenient 3-in-1 Model for In Vitro Hepatic Assays
- A Novel, All-Human Hepatic Triculture System
- All-Human Hepatic Tri-Culture System
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