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Genotypes of Primary Human Hepatocytes: Predictability and Considerations

Mary Jane Cunningham, PhD, LifeNet Health LifeSciences Director for Clinical Applications and Services, discusses how the genotype for primary human hepatocytes may be essential to your research and testing. Knowing the donor's genotype can help with stratifying primary human hepatocyte lots used in drug discovery and development assays. 

Key topics include:

  • The basics of genotyping and pharmacogenetics
  • How genotypes relate to the metabolism of Cytochrome P450 isozymes and Phase II molecules
  • How the genotypes for these enzymes can be used in experimental design planning