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Primary Human Hepatocytes in Drug Development: Challenges and Opportunities Part 2

Donald Tweedie, PhD and Ed LeCluyse, PhD continue their former discussion on the challenges and opportunities with using primary human hepatocytes in drug development. 

Drs. Tweedie and LeCluyse have a combined 70 years' experience in drug development and research involving alternative drug metabolism and toxicological methods. Key topics include:

  • The importance of using primary human hepatocytes which retain their native in vivo functions
  • How incorporating non-parenchymal cells in hepatocyte cultures creates a more in vivo-like liver environment
  • The investigative correlation between healthy and diseased liver cells and their incorporation into models for research