Donald Tweedie, PhD and Ed LeCluyse, PhD continue their former discussion on the challenges and opportunities with using primary human hepatocytes in drug development.
Drs. Tweedie and LeCluyse have a combined 70 years' experience in drug development and research involving alternative drug metabolism and toxicological methods. Key topics include:
- The importance of using primary human hepatocytes which retain their native in vivo functions
- How incorporating non-parenchymal cells in hepatocyte cultures creates a more in vivo-like liver environment
- The investigative correlation between healthy and diseased liver cells and their incorporation into models for research