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Utilizing Human Hepatocyte Genotyping Data to Optimize Experimental Design

Mary Jane Cunningham, PhD, explains how the genotyping of primary human hepatocytes may be essential to your experimental design and how knowing the donor’s genotype could help with stratifying hepatocyte lots used in drug discovery and development assays. Topics include:

  • The basics of genotyping and pharmacogenetics
  • How genotypes relate to the metabolism of Cytochrome P450 isozymes and Phase II molecules
  • Use of genotypes for these enzymes in experimental design planning