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Innovation Pipeline

Stem Cells

LifeNet Health LifeSciences continues to lead the way in stem cell development by investigating human induced pluripotent stem cells (iPSC) as viable research solutions. iPSC, derived from human fibroblasts and osteoblasts, have been successfully differentiated into hepatocytes, cardiomyocytes, and neural crest cells. These human iPSC derivatives were differentiated through embryoid body formation and then adherent culture on LifeSciences’ proprietary human-derived extracellular matrix (ECM), HuGentraTM. The success of these cell models on human tissue-derived ECM will further advance discovery and development of new therapies.

iPSC-derived hepatocytes on HuGentraTM stained with albumin and alpha-fetoprotein

iPSC-derived hepatocytes on HuGentraTM stained with albumin and alpha-fetoprotein

Human iPSCs expressing an antigen for embryonic stem cells

Human iPSCs expressing an antigen for embryonic stem cells

iPSC-derived neural cells on HuGentraTM stained with beta-tubulin and A2B5, a stem cell marker

iPSC-derived neural cells on HuGentraTM stained with beta-tubulin and A2B5, a stem cell marker

Beating cardiomyocytes derived from embryoid bodies stained for cardiac troponin

Beating cardiomyocytes derived from embryoid bodies stained for cardiac troponin