Blogs
Get insights into the world of in vitro cell-based research, including the shift toward alternative methods to animal testing, through our blog posts.
Primary human hepatocytes are essential tools for drug discovery, ADME/DMPK, and toxicology studies — but it is important to remember that not all lots are the same. Taking time to ask key questions up front about donor history, histopathology, hepatocyte function, and other issues can help researchers get the best match for each project.
If your company is planning to bring a new drug to market, ADME and toxicology studies must be a part of the early drug discovery process. Performing these in vitro assays allows you to filter out inappropriate drug candidates as early as possible.
The goal of the life sciences field is to design and produce new reagents, technologies, and medical therapies to enhance, heal, and protect human life. In recent decades, there has also been a growing emphasis on moving away from animal-based studies in favor of methods using human cells.
Human tissues have become increasingly important for pre-clinical medical research. While this provides many benefits – including more accurate and relevant results to fuel the development of enhanced drug therapies – it also brings new challenges.
LifeNet Health LifeSciences is committed to partnering with scientists who respect the dignity of our donors. Here Alan J. Grodzinsky, ScD, shares his perspective on how much it means to work with human tissue – and the value it can bring to a project. Dr.
Requesting human biospecimens for drug discovery and other projects can be challenging. Hurdles include navigating the approval process and making decisions that can have a downstream impact on availability, timelines, and costs. Considering many of these details ahead of time, including how they might impact your project, can help the process go more smoothly.
LifeNet Health LifeSciences is committed to championing women who are paving the way in science. This month, in honor of International Women’s Day, we’re featuring some of our women scientists.
LifeNet Health LifeSciences is committed to championing women who are paving the way in science. This month, in honor of International Women’s Day, we’re featuring some of our women scientists.
Increasingly, use of human tissues is becoming a must-have in biomedical research during every stage of the drug discovery pipeline. This is a fundamental shift that can help us develop safer, more effective treatments, as well as a deeper understanding of disease processes.
Kupffer cells (KC) constitute the largest population of liver macrophages, representing 80-90% of the total tissue macrophages in the body. As resident liver macrophages, KCs are a component of the walls of the hepatic sinusoids.