Skin Permeation Testing
Dermal absorption is a primary consideration in determining the safety and/or efficacy of a dermatological product. As animal skin models do not accurately mimic that of human skin, the “gold standard” barrier for skin permeation testing consists of using excised human skin.
Significance of Skin Permeation Testing
Skin permeation testing aids researchers understand the physiochemical properties of the active pharmaceutical ingredient and its ability to reach the targeted skin layer and systemic circulation. Differing properties in the active ingredients impact the:
- Penetration to the targeted layer
- Assessment of local and systemic risks
- Development of new formulations
Our Process Sets Us Apart from Other Laboratories
For over 40 years, LifeNet Health LifeSciences has existed as a global leader in tissue banking and organ procurement and has an extensive, industry leading portfolio of dermal allographs. Together, these attributes and experience have allowed us to provide high quality, excised human skin, and to process the skin for dermal absorption testing.
Our services team offers a standardized protocol for assessing skin permeation based on the OECD 428: Skin Absorption: In Vitro Method. This ensures high-quality data with the speed and accuracy needed for early drug discovery. We provide study designs suitable for IND submissions and collaborate with you to tailor the study to your specific research needs.
Benefits of Our Services:
- Accurate and reliable data for informed decision making
- Fast turnaround times to keep your drug development on track
- Unsurpassed expertise and quality control from the donor gift to assay testing
- Collaborative approach to ensure the study addresses your research questions
